Analysis of miRNAs involved in mouse brain injury upon Coxsackievirus A6 infection.

ABSTRACT:

Introduction

Coxsackievirus A6 (CV-A6) has emerged as the predominant epidemic strain responsible for hand, foot and mouth disease (HFMD). CV-A6 infection can result in severe clinical manifestations, including encephalitis, meningitis, and potentially life-threatening central nervous system disorders. Our previous research findings demonstrated that neonatal mice infected with CV-A6 exhibited limb weakness, paralysis, and ultimately succumbed to death. However, the underlying mechanism of CV-A6-induced nervous system injury remains elusive. Numerous reports have highlighted the pivotal role of miRNAs in various viral infections.

Methods

Separately established infection and control groups of mice were used to create miRNA profiles of the brain tissues before and after CV-A6

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11374775 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature