Psychometric Assessment of the Rett Syndrome Caregiver Assessment of Symptom Severity (RCASS).

ABSTRACT: Rett syndrome is a severe neurodevelopmental disorder that affects about 1 in 10,000 females. Clinical trials of disease modifying therapies are on the rise, but there are few psychometrically sound caregiver-reported outcome measures available to assess treatment benefit. We report on a new caregiver-reported outcome measure, the Rett Caregiver Assessment of Symptom Severity (RCASS). Using data from the Rett Natural History Study (n = 649), we examined the factor structure, using both exploratory and confirmatory factor analysis, and the reliability and validity of the RCASS. The four-factor model had the best overall fit, which covered movement, communication, behavior, and Rett-specific symptoms. The RCASS had moderate internal consistency. Strong face validity was found with age and mu

SUBMITTER: Raspa M 

PROVIDER: S-EPMC11374935 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature