Nonlinear relationship between the triglyceride-glucose index and alanine aminotransferase in children with short stature.

ABSTRACT: Metabolic dysfunction associated fatty liver disease (MAFLD) is a common cause of liver disease in children and adolescents. The relationship between insulin resistance (IR) and MAFLD in children with short stature remains largely unknown. The present study was to investigate the relationship between the triglyceride-glucose (TyG) index and alanine aminotransferase (ALT) levels in children with short stature. A total of 1754 children with short stature were enrolled. Anthropometric, biochemical and hormonal indexes were collected through physical measurement examinations and laboratory tests. A nonlinear association was found between the TyG index and ALT. The inflection point of the curve was at a TyG index of 8.24. In multivariate piecewise linear regression, only when the TyG index was

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC11374982 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature