Sex differences in functional cortical organization reflect differences in network topology rather than cortical morphometry.

ABSTRACT: Differences in brain size between the sexes are consistently reported. However, the consequences of this anatomical difference on sex differences in intrinsic brain function remain unclear. In the current study, we investigate whether sex differences in intrinsic cortical functional organization may be associated with differences in cortical morphometry, namely different measures of brain size, microstructure, and the geodesic distance of connectivity profiles. For this, we compute a low dimensional representation of functional cortical organization, the sensory-association axis, and identify widespread sex differences. Contrary to our expectations, sex differences in functional organization do not appear to be systematically associated with differences in total surface area, microstructur

SUBMITTER: Serio B 

PROVIDER: S-EPMC11375086 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature