Nymphaea alba leaf powder effectiveness in removing nisin from fermentation broth using docking and experimental analysis.

ABSTRACT: The accumulation of nisin in the fermentation medium can reduce the process's productivity. This research studied the potential of Nymphaea alba leaf powder (NALP) as a hydrophobic biosorbent for efficient in-situ nisin adsorption from the fermentation medium by docking and experimental analysis. Molecular docking analysis showed that di-galloyl ellagic acid, a phytochemical compound found in N. alba, had the highest affinity towards nisin. Enhancements in nisin adsorption were seen following pre-treatment of NAPL with HCl and MgCl₂. A logistic growth model was employed to evaluate the growth dynamics of the biosorption capacity, offering valuable insights for process scalability. Furthermore, optimization through Response Surface Methodology elucidated optimal nisin desorption

SUBMITTER: Khazravi L 

PROVIDER: S-EPMC11375215 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature