Dynamic Risk Model for the Medical Treatment of Graves' Hyperthyroidism according to Treatment Duration.

ABSTRACT:

Backgruound

Changes in thyrotropin receptor antibody (TRAb) levels are associated with the clinical outcomes of Graves' hyperthyroidism. However, the effects of the patterns of TRAb changes on patient prognosis according to the treatment duration of antithyroid drugs (ATDs) are not well established.

Methods

In this retrospective cohort study, 1,235 patients with Graves' hyperthyroidism who were treated with ATDs for more than 12 months were included. Patients were divided into two groups according to treatment duration: group 1 (12-24 months) and group 2 (>24 months). Risk prediction models comprising age, sex, and either TRAb levels at ATD withdrawal (model A) or patterns of TRAb changes (model B) were compared.

Results

The median treatment duration in groups 1 (n=66

SUBMITTER: Jin M 

PROVIDER: S-EPMC11375307 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature