Gut microbial subtypes and clinicopathological value for colorectal cancer.

ABSTRACT:

Background

Gut bacteria are related to colorectal cancer (CRC) and its clinicopathologic characteristics.

Objective

To develop gut bacterial subtypes and explore potential microbial targets for CRC.

Methods

Stool samples from 914 volunteers (376 CRCs, 363 advanced adenomas, and 175 normal controls) were included for 16S rRNA sequencing. Unsupervised learning was used to generate gut microbial subtypes. Gut bacterial community composition and clustering effects were plotted. Differences of gut bacterial abundance were analyzed. Then, the association of CRC-associated bacteria with subtypes and the association of gut bacteria with clinical information were assessed. The CatBoost models based on gut differential bacteria were constructed to identify the diseases includin

SUBMITTER: Han S 

PROVIDER: S-EPMC11375334 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature