Diagnostic Performance of GFAP, UCH-L1, and MAP-2 Within 30 and 60 Minutes of Traumatic Brain Injury.

ABSTRACT:

Importance

Data on the performance of traumatic brain injury (TBI) biomarkers within minutes of injury are lacking.

Objectives

To examine the performance of glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and microtubule-associated protein 2 (MAP-2) within 30 and 60 minutes of TBI in identifying intracranial lesions on computed tomography (CT) scan, need for neurosurgical intervention (NSI), and clinically important early outcomes (CIEO).

Design, setting, and participants

This cohort study is a biomarker analysis of a multicenter prehospital TBI cohort from the Prehospital Tranexamic Acid Use for TBI clinical trial conducted across 20 centers and 39 emergency medical systems in North America from May 2015 to March 2017. Prehos

SUBMITTER: Papa L 

PROVIDER: S-EPMC11375473 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature