Expression of signal recognition particle 14 in hepatocellular carcinoma and its relationship with disease progression and patient survival.

ABSTRACT:

Objectives

To investigate the expression of signal recognition particle 14 (SRP14) in hepatocellular carcinoma (HCC) and its clinical significance.

Methods

The data of SRP14 expression in HCC were obtained from bioinformatics study, and from investigation with quantitative reverse transcription polymerase chain reaction (qRT-PCR), immunohistochemical staining and Western blotting in clinical samples. The Kaplan-Meier analysis was used to determine the associations between SRP14 mRNA expression and the overall survival, progression-free survival, and disease-specific survival of HCC patients. The effect of SRP14 on the proliferation and migration of HCC cells were determined by EdU staining, MTS, Transwell and wound-healing assays. The potential mechanism for SRP14 reg

SUBMITTER: Tian H 

PROVIDER: S-EPMC11375497 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature