Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia.

ABSTRACT:

Importance

Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia predominantly affecting Black female individuals. Current conventional treatments target inflammation but not the underlying fibrotic processes, often leading to permanent hair loss.

Objective

To investigate the associations of low-dose oral metformin, an antidiabetic medication with antifibrotic properties, with clinical symptoms and scalp gene expression patterns in patients with CCCA.

Design, setting, and participants

This retrospective clinical case series and transcriptomic analysis included patients treated at a single tertiary academic medical center between January 2023 and March 2024. All patients had biopsy-confirmed CCCA refractory to standard treatments. Transcriptomic analys

SUBMITTER: Bao A 

PROVIDER: S-EPMC11375521 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature