Genome-Wide Association Study of Accessory Atrioventricular Pathways.

ABSTRACT:

Importance

Understanding of the genetics of accessory atrioventricular pathways (APs) and affiliated arrhythmias is limited.

Objective

To investigate the genetics of APs and affiliated arrhythmias.

Design, setting, and participants

This was a genome-wide association study (GWAS) of APs, defined by International Classification of Diseases (ICD) codes and/or confirmed by electrophysiology (EP) study. Genome-wide significant AP variants were tested for association with AP-affiliated arrhythmias: paroxysmal supraventricular tachycardia (PSVT), atrial fibrillation (AF), ventricular tachycardia, and cardiac arrest. AP variants were also tested in data on other heart diseases and measures of cardiac physiology. Individuals with APs and control individuals from Iceland (deCOD

SUBMITTER: Aegisdottir HM 

PROVIDER: S-EPMC11375522 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature