Comprehensive Analysis of CCAAT/Enhancer Binding Protein Family in Ovarian Cancer.

ABSTRACT:

Background

Ovarian cancer has brought serious threats to female health. CCAAT/enhancer binding proteins (C/EBPs) are key transcription factors involved in ovarian cancer. Therefore, comprehensive profiling C/EBPs in ovarian cancer is needed.

Methods

A comprehensive analysis concerning C/EBPs in ovarian cancer was performed. Firstly, detailed expression of C/EBP family members was integrally retrieved and then confirmed using immunohistochemistry. The regulatory effects and transcription regulatory functions of C/EBPs were studied by using regulatory network analysis and enrichment analysis. Using survival analysis, receiver operating characteristic curve analysis, and target-disease association analysis, the predictive prognostic value of C/EBPs on survival and drug responsi

SUBMITTER: Tan J 

PROVIDER: S-EPMC11375656 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature