Early Preclinical Studies of Ergosterol Peroxide and Biological Evaluation of Its Derivatives.

ABSTRACT: Ganoderma lucidum is a medicinal mushroom that produces various pharmacological compounds, including triterpenoids. A major bioactive component of G. lucidum is ergosterol peroxide (EP), which is attributed to its anticancer effects. The current study focuses on the in vitro ADME (absorption, distribution, metabolism, and elimination), in vivo efficacy and toxicity of EP, and the synthesis of new EP derivatives to improve aqueous solubility. It was found that EP is metabolically stable in liver microsomes and plasma. In vivo studies showed that EP inhibits tumor growth in murine cancer models, and it is well tolerated by mice. The maximum tolerated dose was investigated in mice at escalating doses with a defined maximum amount of 500 mg/kg, which indicate

SUBMITTER: Ling T 

PROVIDER: S-EPMC11375702 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature