Molybdenum Disulfide Nanosheet-Based Nanocomposite for the Topical Delivery of Umbelliferone: Evaluation of Anti-inflammatory and Analgesic Potentials.

ABSTRACT: This study aimed to develop a nanocomposite formulation comprising umbelliferone (UMB) and molybdenum disulfide (MoS₂) nanosheets as a carrier, termed as the UMB-MoS₂ nanocomposite in gel for topical delivery. MoS₂ nanosheets were successfully synthesized via a green-hydrothermal reaction of 10 mg of ammonium molybdate and 10 mg of thiourea in 80 mL of deionized water under predetermined conditions. The UMB-MoS₂ nanocomposite was prepared by sonicating UMB and MoS₂ nanosheets (each of 1 mg/mL) in dimethylformamide. Scanning electron microscopy revealed crumpled nanosheets with an open-ended structure and a nanocomposite as a layered structure. The X-ray diffraction pattern revealed the amorphous nature of UMB in the UMB-MoS₂

SUBMITTER: Lal DK 

PROVIDER: S-EPMC11375718 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature