Modern antiretroviral regimens in pregnant women: virologic outcomes and durability.

ABSTRACT:

Objectives

Data are lacking on the virologic efficacy and durability of modern antiretroviral treatment (ART) regimens during pregnancy. We compared virologic outcomes at delivery among women receiving dolutegravir versus other ART and the rate of change of the initial pregnancy regimen.

Design

Single-site retrospective cohort between 2009 and 2019.

Methods

We used univariable and multivariable generalized estimating equations to model the relationship between the maternal ART anchor and the proportion of women with a detectable viral load (greater than or equal to 20 HIV RNA copies/mL of plasma) closest to delivery (suboptimal virologic control) and with a detectable viral load at any time in the third trimester. We also compared changes in ART during pregnancy.

R

SUBMITTER: Smith C 

PROVIDER: S-EPMC11375792 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature