Investigating Additive and Replacing Horizontal Gene Transfers Using Phylogenies and Whole Genomes.

ABSTRACT: Horizontal gene transfer (HGT) is fundamental to microbial evolution and adaptation. When a gene is horizontally transferred, it may either add itself as a new gene to the recipient genome (possibly displacing nonhomologous genes) or replace an existing homologous gene. Currently, studies do not usually distinguish between "additive" and "replacing" HGTs, and their relative frequencies, integration mechanisms, and specific roles in microbial evolution are poorly understood. In this work, we develop a novel computational framework for large-scale classification of HGTs as either additive or replacing. Our framework leverages recently developed phylogenetic approaches for HGT detection and classifies HGTs inferred between terminal edges based on gene orderings along genomes and phylogenetic

SUBMITTER: Kloub L 

PROVIDER: S-EPMC11375855 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature