SEPT9: From pan-cancer to lung squamous cell carcinoma.

ABSTRACT:

Background

SEPT9 is a pivotal cytoskeletal GTPase that regulates diverse biological processes encompassing mitosis and cytokinesis. While previous studies have implicated SEPT9 in tumorigenesis and development; comprehensive pan-cancer analyses have not been performed. This study aims to systematically explore its role in cancer screening, prognosis, and treatment, addressing this critical gap.

Methods

Gene and protein expression data containing clinical information were obtained from public databases for pan-cancer analyses. Additionally, clinical samples from 90 patients with lung squamous cell carcinoma (LUSC) were used to further experimentally validate the clinical significance of SEPT9. In addition, the molecular docking tool was used to analyze the affinities between

SUBMITTER: Wang W 

PROVIDER: S-EPMC11375884 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature