3D Bioprinted Hydrogel Microfluidic Devices for Parallel Drug Screening.

ABSTRACT: Conventional high-throughput screening (HTS) platforms suffer from the need for large cell volumes, high reagent consumption, significant assembly cost, and handling efforts. The assembly of three-dimensional (3D) bioprinted hydrogel-based microfluidic chips within platforms can address these problems. We present a continuous and seamless manufacturing approach to create a bioprinted microfluidic chips with a circular pattern scalable toward HTS platforms. Digital light processing 3D bioprinting is used to tune the local permeability of our chip, made of polyethylene glycol diacrylate and cell-laden gelatin methacryloyl, for creating predefined gradients of biochemical properties. We measured the flow-induced physical characteristics, the mass transport of drug agents, and the biological f

SUBMITTER: Bhusal A 

PROVIDER: S-EPMC11375967 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature