High density information storage through isotope ratio encoding.

ABSTRACT: The need for reliable information storage is on a steep rise. Sequence-defined polymers, particularly oligonucleotides, are already in use in several areas, while compound mixtures also offer a simple way for storing information. We investigated the use of a set of isotopologues in information storage by mixing, where the information is stored in the form of a mass spectrometric (MS) fingerprint of the mixture. A small molecule with 24 non-labile and replaceable hydrogen atoms was selected as a model, and a set of components covering the D₀-D₂₄ deuteration range were synthesized. Theoretical analysis predicted that by mixing up to 10 out of the prepared components, one can encode over 130 million different combinations and distinguish their MS fingerprints. As a proof

SUBMITTER: Soregi P 

PROVIDER: S-EPMC11376023 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature