Surefire generation of stannylpotassium: highly reactive stannyl anions and applications.

ABSTRACT: Organometallic reagents such as organolithium and Grignard reagents have long been esteemed in chemical synthesis for their exceptional reactivity. In contrast, the application of their sodium and potassium counterparts has been comparatively sluggish, notwithstanding their augmented reactivity stemming from their heightened ionic character. This inertia persists due to the constrained accessibility of these heavy alkali metal reagents. In this study, our focus was directed towards devising a convenient and pragmatic approach for fabricating heavy alkali metal-based reagents, particularly those grounded in potassium. Herein, we present a novel, direct method for generating stannylpotassium (Sn-K) reagents through the simple combination of readily available silylstannanes and t-BuOK.

SUBMITTER: Hiraoka Y 

PROVIDER: S-EPMC11376058 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature