Selective alteration of gene expression in response to natural and synthetic retinoids.

ABSTRACT:

Background

Retinoids are very potent inducers of cellular differentiation and apoptosis, and are efficient anti-tumoral agents. Synthetic retinoids are designed to restrict their toxicity and side effects, mostly by increasing their selectivity toward each isotype of retinoic acids receptors (RARalpha,beta, gamma and RXRalpha, beta, gamma). We however previously showed that retinoids displayed very different abilities to activate retinoid-inducible reporter genes, and that these differential properties were correlated to the ability of a given ligand to promote SRC-1 recruitment by DNA-bound RXR:RAR heterodimers. This suggested that gene-selective modulation could be achieved by structurally distinct retinoids.

Results

Using the differential display mRNA technique, we identi

SUBMITTER: Brand C 

PROVIDER: S-EPMC113761 | biostudies-literature | 2002 May

REPOSITORIES: biostudies-literature