MRGM: an enhanced catalog of mouse gut microbial genomes substantially broadening taxonomic and functional landscapes.

ABSTRACT: Mouse gut microbiome research is pivotal for understanding the human gut microbiome, providing insights into disease modeling, host-microbe interactions, and the dietary influence on the gut microbiome. To enhance the translational value of mouse gut microbiome studies, we need detailed and high-quality catalogs of mouse gut microbial genomes. We introduce the Mouse Reference Gut Microbiome (MRGM), a comprehensive catalog with 42,245 non-redundant mouse gut bacterial genomes across 1,524 species. MRGM marks a 40% increase in the known taxonomic diversity of mouse gut microbes, capturing previously underrepresented lineages through refined genome quality assessment techniques. MRGM not only broadens the taxonomic landscape but also enriches the functional landscape of the mouse gut microbio

SUBMITTER: Kim N 

PROVIDER: S-EPMC11376411 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature