Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation.

ABSTRACT: Inflammatory bowel diseases (IBD) etiology is multifactorial. Luminal microRNAs (miRNAs) have been suspected to play a role in the promotion of chronic inflammation, but the extent to which fecal miRNAs are interacting with the intestinal ecosystem in a way that contribute to diseases, including IBD, remains unknown. Here, fecal let-7b and miR-21 were found elevated, associated with inflammation, and correlating with multiple bacteria in IBD patients and IL-10^-/- mice, model of spontaneous colitis. Using an in vitro microbiota modeling system, we revealed that these two miRNAs can directly modify the composition and function of complex human microbiota, increasing their proinflammatory potential. In vivo investigations revealed that luminal increase of let-7b drast

SUBMITTER: Casado-Bedmar M 

PROVIDER: S-EPMC11376420 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature