Radical surgical resection with molecular margins is associated with improved survival in IDH wild-type glioblastoma.

ABSTRACT:

Background

Survival is variable in patients with glioblastoma IDH wild-type (GBM), even after comparable surgical resection of radiographically detectable disease, highlighting the limitations of radiographic assessment of infiltrative tumor anatomy. The majority of postsurgical progressive events are failures within 2 cm of the resection margin, motivating supramaximal resection strategies to improve local control. However, which patients benefit from such radical resections remains unknown.

Methods

We developed a predictive model to identify which IDH wild-type GBMs are amenable to radiographic gross-total resection (GTR). We then investigated whether GBM survival heterogeneity following GTR is correlated with microscopic tumor burden by analyzing tumor cell content at the

SUBMITTER: Massaad E 

PROVIDER: S-EPMC11376447 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature