Secondary cerebro-cerebellar and intra-cerebellar dysfunction in cerebellar mutism syndrome.

ABSTRACT:

Background

Cerebellar mutism syndrome (CMS) is characterized by deficits of speech, movement, and affect that can occur following tumor removal from the posterior fossa. The role of cerebro-cerebellar tract injuries in the etiology of CMS remains unclear, with recent studies suggesting that cerebro-cerebellar dysfunction may be related to chronic, rather than transient, symptomatology.

Methods

We measured functional connectivity between the cerebellar cortex and functional nodes throughout the brain using fMRI acquired after tumor removal but prior to adjuvant therapy in a cohort of 70 patients diagnosed with medulloblastoma. Surgical lesions were mapped to the infratentorial anatomy, and connectivity with cerebral cortex was tested for statistical dependence on extent of ce

SUBMITTER: McAfee SS 

PROVIDER: S-EPMC11376456 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature