Radiomics-based prediction of local control in patients with brain metastases following postoperative stereotactic radiotherapy.

ABSTRACT:

Background

Surgical resection is the standard of care for patients with large or symptomatic brain metastases (BMs). Despite improved local control after adjuvant stereotactic radiotherapy, the risk of local failure (LF) persists. Therefore, we aimed to develop and externally validate a pre-therapeutic radiomics-based prediction tool to identify patients at high LF risk.

Methods

Data were collected from A Multicenter Analysis of Stereotactic Radiotherapy to the Resection Cavity of BMs (AURORA) retrospective study (training cohort: 253 patients from 2 centers; external test cohort: 99 patients from 5 centers). Radiomic features were extracted from the contrast-enhancing BM (T1-CE MRI sequence) and the surrounding edema (T2-FLAIR sequence). Different combinations of radiomic a

SUBMITTER: Buchner JA 

PROVIDER: S-EPMC11376458 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature