EDA2R reflects the acute brain response to cranial irradiation in liquid biopsies.

ABSTRACT:

Background

Cranial radiotherapy is standard of care for high-grade brain tumors and metastases; however, it induces debilitating neurocognitive impairments in cancer survivors, especially children. As the numbers of pediatric brain cancer survivors continue improving, the numbers of individuals developing life-long neurocognitive sequalae are consequently expected to rise. Yet, there are no established biomarkers estimating the degree of the irradiation-induced brain injury at completion of radiotherapy to predict the severity of the expected neurocognitive complications. We aimed to identify sensitive biomarkers associated with brain response to irradiation that can be measured in easily accessible clinical materials, such as liquid biopsies.

Methods

Juvenile mice were subj

SUBMITTER: Lastra Romero A 

PROVIDER: S-EPMC11376461 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature