Focal spleen lesions in loiasis: A pilot study in Gabon.

ABSTRACT:

Background

Infection with the filarial nematode Loa loa, endemic in Central and Western Africa, has been associated with increased morbidity and mortality. A number of reports described the presence of spleen nodules, originating from degenerating microfilariae, in humans and animals infected with L. loa. The long-term consequences of this process on individuals chronically exposed to infection in terms of spleen function and possible link with excess mortality are unknown. The aim of this study was to evaluate the prevalence of focal spleen lesions, their evolution over time, and markers of spleen function, in individuals with L. loa infection living in highly endemic areas of Gabon.

Methodology/principal findings

This was a cross-sectional study followed by a longitudinal

SUBMITTER: Adegbite BR 

PROVIDER: S-EPMC11376530 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature