Pervasive tissue-, genetic background-, and allele-specific gene expression effects in Drosophila melanogaster.

ABSTRACT: The pervasiveness of gene expression variation and its contribution to phenotypic variation and evolution is well known. This gene expression variation is context dependent, with differences in regulatory architecture often associated with intrinsic and environmental factors, and is modulated by regulatory elements that can act in cis (linked) or in trans (unlinked) relative to the genes they affect. So far, little is known about how this genetic variation affects the evolution of regulatory architecture among closely related tissues during population divergence. To address this question, we analyzed gene expression in the midgut, hindgut, and Malpighian tubule as well as microbiome composition in the two gut tissues in four Drosophila melanogaster strains and their F1 hybrids from two div

SUBMITTER: Glaser-Schmitt A 

PROVIDER: S-EPMC11376557 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature