Genetically influenced tobacco and alcohol use behaviors impact erythroid trait variation.

ABSTRACT: Genome wide association studies (GWAS) have associated thousands of loci with quantitative human blood trait variation. Loci and related genes that impact blood trait variation may regulate blood cell-intrinsic biological processes, or alternatively impact blood cell development and function via systemic factors. Clinical observations have linked tobacco or alcohol use with altered blood traits, but these trait relationships have not been systematically explored at the genetic level. Applying a Mendelian randomization (MR) framework to GWAS summary statistics, we explore relationships between smoking and drinking behaviors with 15 quantitative blood traits. We find that the effects of smoking and drinking are confined to red blood cell traits. An instrumental variable (IV) comprised of 113

SUBMITTER: Shivakumar S 

PROVIDER: S-EPMC11376579 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature