A systematic review and network meta-analysis of psychological, psychosocial, pharmacological, physical and combined treatments for adults with a new episode of depression.

ABSTRACT:

Background

Various effective treatments for depression exist. We aimed to identify the most effective first-line treatments for new episodes of less and more severe depression (defined by depression scale cut-off scores), to update NICE guidance on the management of Depression in Adults in England.

Methods

Systematic review and network meta-analysis of randomised controlled trials (RCTs) published up to June 2020 (PROSPERO registration number CRD42019151328). We analysed interventions by class and individually. The primary efficacy outcome was depressive symptom change (expressed as standardised mean difference [SMD]). The review for this outcome was updated in November 2023.

Findings

We included 676 RCTs, 105,477 participants and 63 treatment classes. For less severe

SUBMITTER: Mavranezouli I 

PROVIDER: S-EPMC11377144 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature