Investigating the effects of Ginkgo biloba leaf extract on cognitive function in Alzheimer's disease.

ABSTRACT:

Aims

Alzheimer's disease (AD) is a neurodegenerative disorder with limited treatment options. This study aimed to investigate the therapeutic effects of Ginkgo biloba leaf extract (GBE) on AD and explore its potential mechanisms of action.

Methods

Key chemical components of GBE, including quercetin, luteolin, and kaempferol, were identified using network pharmacology methods. Bioinformatics analysis revealed their potential roles in AD through modulation of the PI3K/AKT/NF-κB signaling pathway.

Results

Mouse experiments demonstrated that GBE improved cognitive function, enhanced neuronal morphology, and reduced serum inflammatory factors. Additionally, GBE modulated the expression of relevant proteins and mRNA.

Conclusion

GBE shows promise as a potential treatm

SUBMITTER: Zhu C 

PROVIDER: S-EPMC11377177 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature