Perturbed maternal microbiota shapes offspring microbiota during early colonization period in mice.

ABSTRACT: Recent studies have highlighted the impact of disrupted maternal gut microbiota on the colonization of offspring gut microbiota, with implications for offspring developmental trajectories. The extent to which offspring inherit the characteristics of altered maternal gut microbiota remains elusive. In this study, we employed a mouse model where maternal gut microbiota disruption was induced using non-absorbable antibiotics. Systematic chronological analyses of dam fecal samples, offspring luminal content, and offspring gut tissue samples revealed a notable congruence between offspring gut microbiota profiles and those of the perturbed maternal gut microbiota, highlighting the profound influence of maternal microbiota on early-life colonization of offspring gut microbiota. Nonetheless, certa

SUBMITTER: Tochitani S 

PROVIDER: S-EPMC11377213 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature