Zinc dampens antitumor immunity by promoting Foxp3⁺ regulatory T cells.

ABSTRACT:

Introduction

The role of zinc (Zn) in tumor development and immune modulation has always been paradoxical. This study redefines our understanding of the impact of Zn on cancer progression and therapeutic strategies.

Methods

We investigated the effects of dietary Zn levels on tumor progression and immune responses. This included examining the impact of both high and deficient dietary Zn, as well as Zn chelation, on tumor growth and immune cell populations. Specifically, we analyzed the frequency of Foxp3⁺ regulatory T-cells (Tregs) and identified the role of FOXO1 in Zn-mediated effects on Tregs. Additionally, we explored the therapeutic potential of clioquinol (CQ) in enhancing ^α-PD-1 immunotherapy responses, particularly in melanoma.

Results

Our

SUBMITTER: Narayan S 

PROVIDER: S-EPMC11377231 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature