Meta-analysis of structural and functional brain abnormalities in early-onset schizophrenia.

ABSTRACT:

Background

Previous studies based on resting-state functional magnetic resonance imaging(rs-fMRI) and voxel-based morphometry (VBM) have demonstrated significant abnormalities in brain structure and resting-state functional brain activity in patients with early-onset schizophrenia (EOS), compared with healthy controls (HCs), and these alterations were closely related to the pathogenesis of EOS. However, previous studies suffer from the limitations of small sample sizes and high heterogeneity of results. Therefore, the present study aimed to effectively integrate previous studies to identify common and specific brain functional and structural abnormalities in patients with EOS.

Methods

The PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure (CNKI), and W

SUBMITTER: Wang L 

PROVIDER: S-EPMC11377232 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature