Evaluation of inflammatory biomarkers and their association with anti-SARS-CoV-2 antibody titers in healthcare workers vaccinated with BNT162B2.

ABSTRACT:

Introduction

Vaccine-induced immunity against COVID-19 generates antibody and lymphocyte responses. However, variability in antibody titers has been observed after vaccination, and the determinants of a better response should be studied. The main objective of this investigation was to analyze the inflammatory biomarker response induced in healthcare workers vaccinated with BNT162b2, and its association with anti-Spike (a SARS-CoV-2 antigen) antibodies measured throughout a 1-year follow-up.

Methods

Anti-spike antibodies and 92 biomarkers were analyzed in serum, along with socio-demographic and clinical variables collected by interview or exploration.

Results

In our study, four biomarkers (ADA, IL-17C, CCL25 and CD8α) increased their expression after the first vaccine

SUBMITTER: Leno-Duran E 

PROVIDER: S-EPMC11377239 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature