Cross-sectional comparison of the association between three different insulin resistance surrogates and frailty: NHANES 1999-2018.

ABSTRACT:

Background

The correlation between various insulin resistance surrogates and frailty remains under investigation in the scientific community.

Methods

Data from NHANES (1999-2018) were used. We utilized weighted binary logistic regression, trend tests, RCS analysis, and subgroup analysis to comprehensively assess the link between METS-IR, HOMA-IR, and TyG, and frailty risk.

Results

The results revealed a significant positive association between high levels of METS-IR, HOMA-IR, and TyG with the risk of frailty in all models. Notably, in model 4, the highest quintile of METS-IR showed the strongest link (OR: 2.960, 95% CI: 2.219-3.949), with HOMA-IR (OR: 2.522, 95% CI: 1.927-3.301) following closely behind. Trend tests revealed a positive trend between METS-IR, HOMA-IR,

SUBMITTER: Lai T 

PROVIDER: S-EPMC11377286 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature