The relationship between lipoproteins and the risk of esophageal cancer: a Mendelian randomization study.

ABSTRACT:

Backgrounds and aims

Esophageal cancer (EC) causes approximately 508,000 deaths annually, making it a significant cause of cancer-related mortality. While previous studies have suggested an association between lipoprotein levels and EC risk, the causal relationship remains unexplored. This study aims to investigate the causal link between lipoproteins and EC using Mendelian randomization (MR).

Methods and findings

This study employed MR to determine the causal effect between lipoproteins and EC risk, with body mass index (BMI) used as a confounder in multivariable MR (MVMR) analysis. Sensitivity analyses were conducted to assess the reliability of the results. Univariable MR (UVMR) analysis indicated that low-density lipoprotein (LDL) had a significant inverse association wi

SUBMITTER: Cui J 

PROVIDER: S-EPMC11377315 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature