Comprehensive understanding of the adverse effects associated with temozolomide: a disproportionate analysis based on the FAERS database.

ABSTRACT:

Background

Temozolomide, which is the standard drug for glioma treatment, has several Adverse events (AEs) in the treatment of gliomas and other tumors that are not yet fully understood. This is due to the pharmacological nature of the alkylating agent. A significant proportion of these effects have not been systematically documented or reported.

Methods

We selected data from the United States FDA Adverse Event Reporting System (FAERS) database from the first quarter of 2004 to the fourth quarter of 2023. Four algorithms were used for disproportionate analysis, with the objective of assessing the association between temozolomide and related adverse events.

Results

In this study, 20,079,906 case reports were collected from the FAERS database, of which 15,152 adverse ev

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11377320 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature