Immunogenomic features of radiologically distinctive nodules in multiple primary lung cancer.

ABSTRACT:

Objectives

To provide molecular and immunological attributes mechanistic insights for the management of radiologically distinctive multiple primary lung cancer (MPLC).

Methods

The Bulk RNA-seq data of MPLC were obtained from our center. The Bulk RNA-seq data and CT images of patients with single primary lung cancer (SPLC) were obtained from GSE103584. Immune infiltration algorithms were performed to investigate the disparities in the immunological microenvironment between the two groups. Single-cell gene analysis was used to explore immune cells composition and communication relationships between cells in MPLC.

Results

In MPLC, 11 pure ground-glass opacity nodules (pGGN) and 10 mixed GGN (mGGN) were identified, while in SPLC, the numbers were 18 pGGN and 22 mGGN, resp

SUBMITTER: Chen MC 

PROVIDER: S-EPMC11377372 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature