Increasing monocytes after lung cancer surgery triggers the outgrowth of distant metastases, causing recurrence.

ABSTRACT: Patients with lung cancer have a high incidence of tumor recurrence even after curative surgical resection. Some reports indicated that immunosuppressive cells induced by surgical stress could contribute to tumor recurrence after surgery; however, the underlying mechanisms are not fully understood. In this study, we found that increased postoperative blood monocytes served as a risk factor for tumor recurrence in 192 patients with non-small cell lung cancer (NSCLC). We established the lung cancer recurrent mouse model after tumor resection and showed that the surgical stress immediately increased the level of serum monocyte chemoattractant protein-1 (MCP-1), which subsequently increased blood monocytes. These blood monocytes were rapidly recruited into distant micrometastases and became tu

SUBMITTER: Kawaguchi Y 

PROVIDER: S-EPMC11377378 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature