Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice.

ABSTRACT: Sepsis is life-threatening condition that can trigger long-term neurological sequelae, including cognitive impairment in survivors. The pathogenesis of the so-called sickness behavior is poorly understood, but sepsis-driven neuroinflammation is thought to play a key role. Microglia are the central nervous system resident immune cells and play major roles in the induction and the control of neuroinflammatory processes. Accordingly, we recently demonstrated important microglia reaction, characterized by dramatic microglia transcriptome remodeling, in an experimental model of sepsis. Interfering with microglia pathways thus represents an interesting opportunity to tune microglia reaction towards beneficial outcomes. Purinergic signaling is central to microglia biology and controls key microgl

SUBMITTER: Paola N 

PROVIDER: S-EPMC11377396 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature