Longitudinal evaluation of polyneuropathy in Parkinson's disease.

ABSTRACT:

Background

Increasing evidence indicates a higher prevalence of polyneuropathy (PNP) in Parkinson's disease (PD). However, the involvement of large fiber neuropathy in PD still remains poorly understood. Given the lack of longitudinal data, we investigated the course of PNP associated with PD.

Methods

In total, 41 PD patients underwent comprehensive clinical evaluation including motor and non-motor assessments as well as nerve conduction studies at baseline and at 2 years of follow-up. The definition of PNP was based on electrophysiological standard criteria. Common causes of PNP were excluded.

Results

At baseline, PNP was diagnosed in 65.85% of PD patients via electroneurography. Patients with PNP presented with higher age (p = 0.019) and PD motor symptom severity (U

SUBMITTER: Kwon EH 

PROVIDER: S-EPMC11377511 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature