Conservative or liberal oxygen targets in patients on venoarterial extracorporeal membrane oxygenation.

ABSTRACT:

Purpose

Patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) frequently develop arterial hyperoxaemia, which may be harmful. However, lower oxygen saturation targets may also lead to harmful episodes of hypoxaemia.

Methods

In this registry-embedded, multicentre trial, we randomly assigned adult patients receiving VA-ECMO in an intensive care unit (ICU) to either a conservative (target SaO₂ 92-96%) or to a liberal oxygen strategy (target SaO₂ 97-100%) through controlled oxygen administration via the ventilator and ECMO gas blender. The primary outcome was the number of ICU-free days to day 28. Secondary outcomes included ICU-free days to day 60, mortality, ECMO and ventilation duration, ICU and hospital lengths of stay, and funct

SUBMITTER: Burrell A 

PROVIDER: S-EPMC11377512 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature