Impact of time intervals on drug efficacy and phenotypic outcomes in acute respiratory distress syndrome in mice.

ABSTRACT: Acute respiratory distress syndrome is a severe lung condition resulting from various causes, with life-threatening consequences that necessitate intensive care. The phenomenon can be modeled in preclinical models, notably through the use of lipopolysaccharide (LPS) instillation in mice. The phenotype induced closely recapitulates the human syndrome, including pulmonary edema, leukocyte infiltration, acute inflammation, impaired pulmonary function, and histological damage. However, the experimental designs using LPS instillations are extremely diverse in the literature. This highly complicates the interpretation of the induced phenotype chronology for future study design and hinders the proper identification of the optimal time frame to assess different readouts. Therefore, the definition

SUBMITTER: Paris-Robidas S 

PROVIDER: S-EPMC11377577 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature