Highly sensitive magnetic particle imaging of abdominal aortic aneurysm NETosis with anti-Ly6G iron oxide nanoparticles.

ABSTRACT: Abdominal aortic aneurysms (AAA) are a significant health concern in developed countries due to their considerable mortality rate. The crucial factor of the progression of AAA is the release of neutrophils and neutrophil extracellular traps (NETs). Magnetic particle imaging (MPI) is a new imaging technique that offers the capability to detect superparamagnetic iron oxide nanoparticles (SPION) with exceptional sensitivity. We aimed to investigate the functional imaging of MPI for the detection and monitoring of neutrophil infiltration within AAA. A novel multimodal imaging agent targeting neutrophils, PEG-Fe₃O₄-Ly6G-Cy7 nanoparticles (Ly6G NPs), were designed by coupling Fe₃O₄ nanoparticles with Ly6G antibodies and Cy7. The targeting and sensitivi

SUBMITTER: Wang H 

PROVIDER: S-EPMC11377588 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature