18F-Flortaucipir (AV1451) imaging identifies grey matter atrophy in retired athletes.

ABSTRACT:

Background

The long-term consequences of concussions may include pathological neurodegeneration as seen in Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE). Tau-PET showed promise as a method to detect tau pathology of CTE, but more studies are needed OBJECTIVE: This study aimed (1) to assess the association of imaging evidence of tau pathology with brain volumes in retired athletes and (2) to examine the relationship between tau-PET and neuropsychological functioning.

Methods

Former contact sport athletes were recruited through the Canadian Football League Alumni Association or the Canadian Concussion Centre clinic. Athletes completed MRI, [¹⁸F]flortaucipir tau-PET, and a neuropsychological battery. Memory composite was created by averaging the

SUBMITTER: Vasilevskaya A 

PROVIDER: S-EPMC11377597 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature