Low β-carotene bioaccessibility and bioavailability from high fat, dairy-based meal.

ABSTRACT:

Purpose

The original aim of the study was to determine, in a double-blind 3-arm crossover human trial (n = 7), the effect of supplemental levels of iron (25 mg) and zinc (30 mg) on β-carotene (synthetic) bioavailability (10 h postprandial). However, despite the high dose of supplemental β-carotene (15 mg) consumed with the high fat (18 g), dairy-based breakfast test meal, there was a negligible postprandial response in plasma and triglyceride rich fraction β-carotene concentrations. We then systematically investigated the possible reasons for this low bioavailability of β-carotene.

Methods

We determined (1) if the supplemental β-carotene could be micellised and absorbed by epithelial cells, using a Caco-2 cell model, (2) if the fat from the test meal was sufficiently bioavai

SUBMITTER: Kruger J 

PROVIDER: S-EPMC11377643 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature