Vitamin C deficiency after kidney transplantation: a cohort and cross-sectional study of the TransplantLines biobank.

ABSTRACT:

Purpose

Vitamin C deficiency is associated with excess mortality in kidney transplant recipients (KTR). We aim to evaluate plasma vitamin C status at different post-transplantation moments and assess the main characteristics associated with vitamin C deficiency in KTR.

Methods

Plasma vitamin C was assessed in 598 KTR at 3-, 6-, 12-, 24-, and 60-months post-transplantation, 374 late KTR with a functioning graft ≥ 1 year, and 395 potential donors. Vitamin C deficiency was defined as plasma vitamin C ≤ 28 µmol/L. Diet was assessed by a 177-item food frequency questionnaire. Data on vitamin C-containing supplements use were extracted from patient records and verified with the patients.

Results

Vitamin C deficiency ranged from 46% (6-months post-transplantation) to 30% (≥ 

SUBMITTER: Yepes-Calderon M 

PROVIDER: S-EPMC11377669 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature