Immune responses to oligomeric α-synuclein in Parkinson's disease peripheral blood mononuclear cells.

ABSTRACT: Parkinson's disease displays clinical heterogeneity, presenting with motor and non-motor symptoms. Heterogeneous phenotypes, named brain-first and body-first, may reflect distinct α-synuclein pathology starting either in the central nervous system or in the periphery. The immune system plays a prominent role in the central and peripheral pathology, with misfolded α-synuclein being placed at the intersection between neurodegeneration and inflammation. Here, we characterized the inflammatory profile and immune-phenotype of peripheral blood mononuclear cells (PBMCs) from Parkinson's disease patients upon stimulation with α-synuclein monomer or oligomer, and investigated relationships of immune parameters with clinical scores of motor and non-motor symptoms. Freshly isolated PBMCs from 21 Park

SUBMITTER: Vega-Benedetti AF 

PROVIDER: S-EPMC11377674 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature